Identify the insect. Determine if the insect is a wasp or a bee. A bee is plumper and has a more round body, while a wasp is long and thin. Wasps will show interest in garbage and food, while bees' interests are flowers and plants. Decide if the bee's nest is truly a nuisance to the area.
Control a concealed nest by applying a small amount of insecticide dust to the nest. Make sure the dust is safe to use in a home environment. If unable to reach the nest, drill a small opening into the wall. Most dust kits come with an applicator or tube to distribute the chemical. Wear a mask so as not to inhale the insecticide.
Determine if all bees have died. Using insecticide can force bees who are in a concealed environment into an enclosed portion---such as inside a home or building. Once all the insects have been removed, caulk the area closed so future nests cannot be built. Winter months are best to treat areas where bees colonize.
Pour a mixture of soap and water into the entrance of a ground nest. The solution can be made of laundry and dish soap. Use insecticide if the bees continue to be a nuisance. Make sure the chemical is safe to use on outdoor soil and grass. Once complete, cover the entrance with soil.
Eradicating an exposed bee's nest should only be performed if the colony is near human activity, and the bees are showing aggression. Spray a ready-to-use wasp and hornet insecticide over the entrance. Check the following day to see if any bees have survived. Spray again if live bees are seen. Remove the dead bees, nest and honeycomb. Seal any areas to prevent further nesting.