Fire ants are aggressive and produce painful stings, sometimes in groups of dozens or even hundreds of ants. Fire ants react quickly to disturbances to their colony, swarming the "attacker" and delivering stinging bites. There are several species of fire ants native to the United States, but the imported red fire ant has colonized much of the southern region of the country. A number of granular baits and liquid insecticides available in retail stores can quickly destroy a fire ant nest, if used properly.
Mix the insecticide with water in a watering can, according to the insecticide's instructions.
Drench all fire ant mounds with the insecticide in the watering can. Start by applying about a quarter of the total volume of the mixture to a 10-to-12-inch band around the outside of the mound. This will prevent the queen from escaping underground.
Apply granular bait using a hand spreader uniformly over your yard. This will prevent fire ant colonies from reemerging after you've destroyed the largest nests.