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How to Use Glyphosate

Ellen Aardvark

Glyphosate is an herbicide used to control and eradicate perennial weeds. It is sprayed in a diluted solution and metabolized by the weed, killing it. The first products on the market containing glyphosate were the Roundup lines. Now, several other brands market products containing glyphosate as an ingredient. Glyphosate products are used in both residential gardens and commercial agriculture. Some new crops have been genetically modified to be resistant to glyphosate so that it can be used to kill weeds without killing the cash crop itself. Glyphosate kills a wide variety of plant life including grasses, leafy and wood bearing plants and is found in herbicide products in varying amounts from 100-grams to over 600-grams per liter. Glysophate products come in either concentrated form designed to be mixed with water or pre-mixed for direct application.

Wear garden gloves and face mask to handle glyphosate products. Determine the dilution measurements according to the directions on the packaging of your particular product.

Pour measured glyphosate product and water into a spray bottle or pump sprayer. Close the lid securely and swirl repeatedly to combine the mixture.

Spray the glyphosate solution directly onto the weeds and any other plants that you wish to eradicate. Do not soak the surrounding soil with solution as it may impair your ability to replant the area.


Glyphosate is a leading herbicide used in the United States and when used in accordance with its directions and dosing recommendations is considered one of the safer herbicides. However, it can be lethal if ingested, so use sparingly and with caution.

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