Begin by procuring the Medusa seeds. This may be your hardest task as the seeds are not terribly popular, though any good garden store should have them in stock. If all else fails, the Internet has many reliable seed merchants. Once you’ve got the seeds, you can go about planting them anytime in spring or early summer.
Pack a perlite growing medium into plain plastic plug trays. These are nothing more than plastic trays with depressions in them large enough to create seedling plugs to sell or transplant once they’ve sprouted. Once you’ve filled the depressions with the growing medium, simply poke a hole about an inch deep into the center of each and place a seed in them. Cover the seed with some more crumbled perlite and water them lightly. Take the time to use a pair of scissors or a knife to cut out the bottoms of each depression in the tray. The packed medium will hold without a complete bottom and this prevents a seedling from becoming rootbound should one sprout early.
Put the plug trays in direct sunlight for about 6 hours a day. If the temperature ever drops below 65 degrees Fahrenheit you should keep the trays indoors in a window sill. The seeds will germinate in 7 to 12 days and can be transplanted 3 weeks after planting.
Prepare a mixture of good lightweight potting soil and peat in a 2:1 ratio and fill the plant pots with it. Remove the plugs from the trays and inspect them. If any of the plants’ roots have curled back on themselves or follow the curve of the tray, you should lightly score them with your scissors before sinking them into the pots, growing medium and all. Water them lightly every day, but stop watering them for a day or two if the leaves begin to wilt or are moist to the touch. The magnesium and calcium needs of this plant are high, though their other nutritional needs are very low. Combine a fertilizer meeting those nutritional needs with and equal measure of Epsom salts. Dilute the mixture with a gallon of water and pour on a tablespoon every other day.
Repel insects using organic methods if you intend to use the peppers that sprout for culinary purposes. Otherwise an over-the-counter pesticide will work just fine. Insects are drawn to the Medusa Pepper because it lacks capsin, which would naturally repel them. Remedy this by mixing up a good amount of hot pepper sauce in water and pouring it over the plants once a week and immediately after a good hard rain. The hotter the pepper sauce, the less you’ll need to use to get the same effect. Your plants should be large enough to produce peppers roughly two months after transplanting, though they should only ever be harvested once they are deep red. From there, you can decide to keep them where they are or plant them in your yard or garden.