Glyphosate is a popular herbicide that is used in products such as Roundup and Pondmaster. It is a non-selective herbicide that can be used to spot-treat weeds. According to the Extension Toxicology Network, glyphosate is popular because it shows no long-term toxicity in animals such as rats, very little toxicity to fish and fowl, and will not leach from organic soil. This makes it one of the safest herbicides for home use because it is an herbicide that is unlikely to harm the environment. Despite this, it is wise to guard against glyphosate overspray that can kill desirable plants and put the herbicide into the soil.
Place a plastic tarp on the ground around weeds that you wish to kill. The tarp will catch any overspray and prevent it from touching desirable plants such as lawn grass.
Attach spray applicator to the bottle of glyphosate. Some glyphosate containers will come with a spray applicator included.
Hold glyphosate spray applicator a few inches away from the weed so that the majority of the spray lands on the weed itself.
Spray glyphosate onto the weed so that the plant is saturated with the herbicide.
Wait for herbicide to dry, then take up the tarp. Roll it inward, so that glyphosate does not touch your skin.