The herbicide Roundup works on pachysandra. Roundup is a postemergent, systemic herbicide that contains glyphosate. It is non-selective and will kill most any annual or perennial that it touches. Roundup is sprayed onto foliage, then moves into the root system, killing the plant.
About this Author
Aileen Clarkson has been an award-winning editor and reporter for more than 20 years, earning three awards from the Society of Professional Journalists. She has worked for several newspapers, including "The Washington Post" and "The Charlotte Observer." Clarkson earned a Bachelor of Arts in journalism from the University of Florida.