Wild blackberries can quickly take over a garden, pasture or fence line. Considered a bramble and a perennial weed, wild blackberries can transmit diseases to domestic brambles grown in a garden setting. One of the most effective ways to remove brambles is through the use of a chemical herbicide. According to the New Jersey Agricultural Experiment Station, the best time to spray wild blackberries is in late summer.
Purchase a chemical herbicide for usage on brambles. The New Jersey Agricultural Experiment Station recommends the use of Roundup as a spot treatment for brambles.
Put on gloves, eye protection and clothing that covers the arms and legs.
Spray the brambles using care to avoid the surrounding grass. Roundup is a non-selective herbicide, which means it will kill any plant it lands on. The ideal day for spraying features little wind and no chance of rain.
Remove the blackberry canes by bush hogging or cutting by hand.