The invasive perennial weedy vine known as Creeping Charlie has been effectively treated using Borax, according to Yard and Garden Brief. Since the 1920s, borax detergent has been used as a herbicide to kill weeds. Use caution when applying borax to your lawn, though, as high concentrations could be toxic to all vegetation. Apply a borax treatment only once a year for two years, switching to a standard herbicide only if the treatment fails.
Apply the borax treatment in the spring, when the Creeping Charlie is active and the weather forecast excludes rain for 48 hours or more.
Dissolve 8 to 10 oz. borax in 1/2 cup water. Add the dissolved borax to a tank sprayer filled with 2-1/2 gallons of water.
Spray the area affected with Creeping Charlie evenly, walking at a consistent pace through your lawn.